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The complexity of nanoparticle dissolution and its importance in nanotoxicological studies
Link to Journal Abstract
Dissolution of nanoparticles (NPs) is an important property that alters their abundance and is often a critical step in determining safety of nanoparticles. The dissolution status of the NPs in exposure media (i.e. whether they remain in particulate form or dissolve — and to what extent), strongly affects the uptake pathway, toxicity mechanisms and the environmental compartment in which NPs will have the highest potential impact. A review of available dissolution data on NPs demonstrates there is a range of potential outcomes depending on the NPs and the exposure media. For example two nominally identical nanoparticles, in terms of size and composition, could have totally different dissolution behaviours, subject to different surface modifications. Therefore, it is imperative that toxicological studies are conducted in conjunction with dissolution of NPs to establish the true biological effect of NPs and hence, assist in their regulation.
This study discusses the dissolution of nanoparticles and physicochemical properties of nanoparticles that influence dissolution as well as how measuring dissolution of nanoparticles can help to understand their biological response.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Material Analysis and Applications
Risk Exposure Group
Science of the Total Environment, 438: 225-232 (November 2012)
Science of the Total Environment
Misra SK, Dybowska A, Berhanu D, Luoma SN, Valsami-Jones E
Last updated on November 15, 2012
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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