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Title:

The complexity of nanoparticle dissolution and its importance in nanotoxicological studies

Date:

11/2012

Link to Journal Abstract

Abstract:

Dissolution of nanoparticles (NPs) is an important property that alters their abundance and is often a critical step in determining safety of nanoparticles. The dissolution status of the NPs in exposure media (i.e. whether they remain in particulate form or dissolve � and to what extent), strongly affects the uptake pathway, toxicity mechanisms and the environmental compartment in which NPs will have the highest potential impact. A review of available dissolution data on NPs demonstrates there is a range of potential outcomes depending on the NPs and the exposure media. For example two nominally identical nanoparticles, in terms of size and composition, could have totally different dissolution behaviours, subject to different surface modifications. Therefore, it is imperative that toxicological studies are conducted in conjunction with dissolution of NPs to establish the true biological effect of NPs and hence, assist in their regulation.

Non-technical Summary:

This study discusses the dissolution of nanoparticles and physicochemical properties of nanoparticles that influence dissolution as well as how measuring dissolution of nanoparticles can help to understand their biological response.

Content Emphasis

Peer Reviewed Journal Article

Exposure Or Hazard Target

Mammalian

Exposure Pathway

Other/Unspecified

Method Of Study

Material Analysis and Applications

Paper Type

Exposure

Particle Type

Other/Unspecified