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Intercellular Carbon Nanotube Translocation Assessed by Flow Cytometry Imaging
Link to Journal Abstract
The fate of carbon nanotubes in the organism is still controversial. Here, we propose a statistical high-throughput imaging method to localize and quantify functionalized multiwalled carbon nanotubes in cells. We give the first experimental evidence of an intercellular translocation of carbon nanotubes. This stress-induced longitudinal transfer of nanomaterials is mediated by cell-released microvesicles known as vectors for intercellular communication. This finding raises new critical issues for nanotoxicology, since carbon nanotubes could be disseminated by circulating extracellular cell-released vesicles and visiting several cells in the course of their passage into the organism.
This paper proposes a statistical high-throughput imaging method to localize and quantify functionalized multiwalled carbon nanotubes in cells and investigates whether carbon nanotubes can be translocated intercellularly using this technique.
Peer Reviewed Journal Article
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Nano Letters, 2012, 12(9): 4830-4837
Marangon I, Boggetto N, Menard-Moyon C, Venturelli E, Beoutis ML, Pechoux C, Luciani N, Wilhelm C, Bianco A, Gazeau F
Last updated on November 15, 2012
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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