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Title:

Intercellular Carbon Nanotube Translocation Assessed by Flow Cytometry Imaging

Date:

9/2012

Link to Journal Abstract

Abstract:

The fate of carbon nanotubes in the organism is still controversial. Here, we propose a statistical high-throughput imaging method to localize and quantify functionalized multiwalled carbon nanotubes in cells. We give the first experimental evidence of an intercellular translocation of carbon nanotubes. This stress-induced longitudinal transfer of nanomaterials is mediated by cell-released microvesicles known as vectors for intercellular communication. This finding raises new critical issues for nanotoxicology, since carbon nanotubes could be disseminated by circulating extracellular cell-released vesicles and visiting several cells in the course of their passage into the organism.

Non-technical Summary:

This paper proposes a statistical high-throughput imaging method to localize and quantify functionalized multiwalled carbon nanotubes in cells and investigates whether carbon nanotubes can be translocated intercellularly using this technique.

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Peer Reviewed Journal Article

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