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Title:

Protective Roles of Single-Wall Carbon Nanotubes in Ultrasonication-Induced DNA Base Damage

Date:

9/2012

Link to Journal Abstract

Abstract:

The overall level of ultrasonication-induced DNA damage is reduced in the presence of single-wall carbon nanotubes (SWCNTs), particularly for DNA lesions formed by one-electron reduction of intermediate radicals. The protective role of SWCNTs observed in this work suggests a contrary view to the general idea that carbon nanotubes have damaging effects on biomolecules.

Non-technical Summary:

For this study, the authors attempt to establish well-controlled in vitro systems to quantitatively examine the effect of single-wall carbon nanotubes (SWCNTs) on biomolecules. High-sensitivity mass spectrometry analysis is used to quantify ultrasonication-induced DNA damage in (ATT)14 and (GT)20 oligomers in the presence and absence of SWCNTs.

Content Emphasis

Peer Reviewed Journal Article

Exposure Or Hazard Target

Mammalian

Exposure Pathway

Other/Unspecified

Method Of Study

Material Analysis and Applications

In Vitro

Paper Type

Hazard

Particle Type