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Protective Roles of Single-Wall Carbon Nanotubes in Ultrasonication-Induced DNA Base Damage
Link to Journal Abstract
The overall level of ultrasonication-induced DNA damage is reduced in the presence of single-wall carbon nanotubes (SWCNTs), particularly for DNA lesions formed by one-electron reduction of intermediate radicals. The protective role of SWCNTs observed in this work suggests a contrary view to the general idea that carbon nanotubes have damaging effects on biomolecules.
For this study, the authors attempt to establish well-controlled in vitro systems to quantitatively examine the effect of single-wall carbon nanotubes (SWCNTs) on biomolecules. High-sensitivity mass spectrometry analysis is used to quantify ultrasonication-induced DNA damage in (ATT)14 and (GT)20 oligomers in the presence and absence of SWCNTs.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Material Analysis and Applications
Risk Exposure Group
Small, 9(2): 205-208 (January 2013)
Petersen EJ, Tu X, Dizdaroglu M, Zheng M, Nelson BC
Last updated on February 1, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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