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Biodistribution study of carbogenic dots in cells and in vivo for optical imaging
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Blue fluorescent carbon dots (C-dots) were synthesized and evaluated for their cytotoxicity and also for their optical imaging performance. The results showed that the C-dots could enter into the Hela cells in 15 min incubation and the uptake increased rapidly from 15 min to 2 h. In cytotoxicity study, C-dots were biocompatible and nontoxic to three human cells including two cancer cells (Hela and SMCC-7721) and one normal cell (HEK 293) in concentrations up to 500 ?g/mL. Since the endocytic interference factors, including NaN3, M?CD, sucrose, and low temperature, could not play an inhibitory effect on C-dots entering into cells, the direct nonendocytic pathway for C-dots was speculated. The C-dots showed encouraging cell-imaging applications in vitro and in vivo. They entered into cells without any further functionalization, and the fluorescence property of these particles can be used for fluorescence-based cell-imaging applications.
For this study, blue fluorescent carbon dots (C-dots) were synthesized and evaluated for their cytotoxicity and also for their optical imaging performance. The cytotoxicity study for the C-dots were determined for three human cells including two cancer cells (Hela and SMCC-7721) and one normal cell (HEK 293).
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Journal of Nanoparticle Research, 14(10): 1177 (October 2012)
Journal of Nanoparticle Research
Li N, Liang X, Wang L, Li Z, Li P, Zhu Y, Song J
1177 (9 pp)
Last updated on November 13, 2012
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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