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Toxicity evaluation of CdTe quantum dots with different size on Escherichia coli
Link to Journal Abstract
Quantum dots (QDs) have a great potential for applications in nanomedicine. However, a few studies showed that they also exhibited toxicity. We used Escherichia coli (E. coli) as the model to study the effect of CdTe QDs on the cell growth by microcalorimetric technique, optical density (OD600) and attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra. Three size aqueous-compatible CdTe QDs with maximum emission of 543 nm (green-emitting QDs, GQDs), 579 nm (yellow-emitting QDs, YQDs) and 647 nm (red-emitting QDs, RQDs) were tested. The growth rate constants (k) and half-inhibiting concentration (IC50) were calculated from the microcalorimetric data. The results indicated that CdTe QDs exhibited a dose-dependent inhibitory effect on cell growth. The order of toxicity is GQDs > YQDs > RQDs. The smaller the particle size of QDs is, the more toxicity it is. ATR-FTIR spectra indicated that the outer membrane of the cell was changed or damaged by the QDs, which may induce QDs and harmful by-products to enter into the cells. These could be one of the reasons that CdTe QDs have cytotoxic effects on E. coli.
In this study, the authors used Escherichia coli (E. coli) as the model to study the effect of CdTe quantum dots (QDs) on the cell growth by microcalorimetric technique, optical density (OD600) and attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Toxicology in Vitro, 26(7): 1233-1239 (October 2012)
Toxicology in Vitro
Fang TT, Li X, Wang QS, Zhang ZJ, Liu P, Zhang CC
Last updated on November 7, 2012
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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