International Council on Nanotechnology

ICON Web & News Virtual Journal Everything

Resources
	Virtual Journal
	Analyze Database
	GoodNanoGuide
	ICON Reports
	ICON Backgrounders
	Glossary
	Policy Reports
	Ratings Comment Guidelines
	Links

Quick Search:
Keywords: Search: Search Using OECD Database

Details

Return to Previous Page

Addition or Correction

Title:

Copper Oxide Nanoparticles Induce Autophagic Cell Death in A549 Cells

Date:

8/2012

Link to Journal Abstract

Abstract:

Metal oxide nanoparticles (NPs) are among the most highly produced nanomaterials, and have many diverse functions in catalysis, environmental remediation, as sensors, and in the production of personal care products. In this study, the toxicity of several widely used metal oxide NPs such as copper oxide, silica, titanium oxide and ferric oxide NPs, were evaluated In vitro. We exposed A549, H1650 and CNE-2Z cell lines to metal oxide NPs, and found CuO NPs to be the most toxic, SiO2 mild toxic, while the other metal oxide NPs had little effect on cell viability. Furthermore, the autophagic biomarker LC3-II significantly increased in A549 cells treated with CuO NPs, and the use of the autophagy inhibitors wortmannin and 3-methyladenin significantly improved cell survival. These results indicate that the cytoxicity of CuO NPs may involve the autophagic pathway in A549 cells.

Non-technical Summary:

In this study, the toxicity of several widely used metal oxide nanoparticles (NPs) such as copper oxide, silica, titanium oxide and ferric oxide NPs, were evaluated In vitro by exposing A549, H1650 and CNE-2Z cell lines to metal oxide NPs.

Content Emphasis

Peer Reviewed Journal Article

Exposure Or Hazard Target

Exposure Pathway

Method Of Study

Paper Type

Particle Type