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In Vitro Cytotoxicity of Rare Earth Oxide Nanoparticles for Imaging Applications
Link to Journal Abstract
The in vitro cytotoxicity and cellular uptake of commercially available doped YVO4 were evaluated in RAW 264.7 macrophages using the MTT assay. The results indicated that 20–50 nm diameter samarium-doped YVO4 showed significant toxicity at concentrations of 25 ?g/mL and higher; samples of the same material functionalized with COOH showed less cytotoxicity. At concentrations of 25–100 ?g/mL, 20–50 nm erbium-doped YVO4 showed less toxicity compared with 20–50 nm samarium-doped YVO4. Ten nanometer samples showed no toxicity at concentrations of 100–600 ?g/mL. The cytotoxicity of rare earth nanoparticles in macrophages is dependent, at least in part, on size and surface functionalization.
For this study, the in vitro cytotoxicity and cellular uptake of commercially available doped YVO4 were evaluated in RAW 264.7 macrophages using the MTT assay.
Peer Reviewed Journal Article
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International Journal of Applied Ceramic Technology, 9(5); 881-892 (Sept/Oct 2012)
International Journal of Applied Ceramic Technology
Petrochenko PE, Zhang Q, Wang H, Sun T, Wildt B, Betz MW, Goering PL, Narayan RJ
Last updated on October 26, 2012
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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