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Title:

In Vitro Cytotoxicity of Rare Earth Oxide Nanoparticles for Imaging Applications

Date:

10/2012

Link to Journal Abstract

Abstract:

The in vitro cytotoxicity and cellular uptake of commercially available doped YVO4 were evaluated in RAW 264.7 macrophages using the MTT assay. The results indicated that 20�50 nm diameter samarium-doped YVO4 showed significant toxicity at concentrations of 25 ?g/mL and higher; samples of the same material functionalized with COOH showed less cytotoxicity. At concentrations of 25�100 ?g/mL, 20�50 nm erbium-doped YVO4 showed less toxicity compared with 20�50 nm samarium-doped YVO4. Ten nanometer samples showed no toxicity at concentrations of 100�600 ?g/mL. The cytotoxicity of rare earth nanoparticles in macrophages is dependent, at least in part, on size and surface functionalization.

Non-technical Summary:

For this study, the in vitro cytotoxicity and cellular uptake of commercially available doped YVO4 were evaluated in RAW 264.7 macrophages using the MTT assay.

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