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Title: Antibacterial Efficiency of Graphene Nanosheets against Pathogenic Bacteria via Lipid Peroxidation
Date: 8/2012
  Link to Journal Abstract
Abstract: Graphene nanosheets are highly recognized for their utility toward the development of biomedical device applications. The present study investigated the antibacterial efficiency of graphene nanosheets against four types of pathogenic bacteria. Graphene nanosheets are synthesized by a hydrothermal approach (under alkaline conditions using hydrazine hydrate). UV–vis and X-ray diffraction show a maximum absorbance at 267 nm and appearance of new broad diffraction peak at 26°, which ensures the reduction of graphene oxide into graphene nanosheets. Stretching and bending vibrations of C–C bonds, chemical states, disorder, and defects associated with the graphene nanosheets are evaluated in comparison with graphene oxide. The minimum inhibitory concentration (MIC) of graphene nanosheets against pathogenic bacteria was evaluated by a microdilution method. MICs such as 1 ?g/mL (against Escherichia coli and Salmonella typhimurium), 8 ?g/mL (against Enterococcus faecalis), and 4 ?g/mL (against Bacillus subtilis) suggest that graphene nanosheets have predominant antibacterial activity compared to the standard antibiotic, kanamycin. Measurement of free radical modulation activity of graphene nanosheets suggested the involvement of reactive oxygen species in antibacterial properties.
Non-technical Summary: This study investigated the antibacterial efficiency of graphene nanosheets against four types of pathogenic bacteria. Graphene nanosheets were synthesized by a hydrothermal approach. The minimum inhibitory concentration (MIC) of graphene nanosheets against pathogenic bacteria was evaluated by a microdilution method.
Content Emphasis Peer Reviewed Journal Article
Exposure Or Hazard Target Other/Unspecified
Exposure Pathway Other/Unspecified
Method Of Study Other
Paper Type Environmental Fate and Transport
Particle Type Carbon
Production Method Engineered
Risk Exposure Group General Population
Target Audience Technical Research
Citation: Journal of Physical Chemistry, C, 2012, 116(32): 17280-17287
Publication: Journal of Physical Chemistry
Author: Krishnamoorthy K, Veerapandian M, Zhang LH, Yun K, Kim SJ
Volume: 116
Number: 32
Pages: 17280-17287
     


Last updated on October 22, 2012
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This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.

 		 
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