ICON Web & News
Search Using OECD Database
Return to Previous Page
Addition or Correction
Antibacterial Efficiency of Graphene Nanosheets against Pathogenic Bacteria via Lipid Peroxidation
Link to Journal Abstract
Graphene nanosheets are highly recognized for their utility toward the development of biomedical device applications. The present study investigated the antibacterial efficiency of graphene nanosheets against four types of pathogenic bacteria. Graphene nanosheets are synthesized by a hydrothermal approach (under alkaline conditions using hydrazine hydrate). UV–vis and X-ray diffraction show a maximum absorbance at 267 nm and appearance of new broad diffraction peak at 26°, which ensures the reduction of graphene oxide into graphene nanosheets. Stretching and bending vibrations of C–C bonds, chemical states, disorder, and defects associated with the graphene nanosheets are evaluated in comparison with graphene oxide. The minimum inhibitory concentration (MIC) of graphene nanosheets against pathogenic bacteria was evaluated by a microdilution method. MICs such as 1 ?g/mL (against Escherichia coli and Salmonella typhimurium), 8 ?g/mL (against Enterococcus faecalis), and 4 ?g/mL (against Bacillus subtilis) suggest that graphene nanosheets have predominant antibacterial activity compared to the standard antibiotic, kanamycin. Measurement of free radical modulation activity of graphene nanosheets suggested the involvement of reactive oxygen species in antibacterial properties.
This study investigated the antibacterial efficiency of graphene nanosheets against four types of pathogenic bacteria. Graphene nanosheets were synthesized by a hydrothermal approach. The minimum inhibitory concentration (MIC) of graphene nanosheets against pathogenic bacteria was evaluated by a microdilution method.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Environmental Fate and Transport
Risk Exposure Group
Journal of Physical Chemistry, C, 2012, 116(32): 17280-17287
Journal of Physical Chemistry
Krishnamoorthy K, Veerapandian M, Zhang LH, Yun K, Kim SJ
Last updated on October 22, 2012
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
Why Join Us?
Mission and Strategy
Good Nano Guide
Nano EHS Research Needs
Current Practices Survey