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Title: Toxicity of CdTe Quantum Dots on Yeast Saccharomyces Cerevisiae
Date: 9/2012
  Link to Journal Abstract
Abstract: Along with the widespread development of their bioapplications, concerns about the biosafety of quantum dots (QDs) have increasingly attracted intensive attention. This study examines the toxic effect and subcellular location of cadmium telluride (CdTe) QDs with different sizes against yeast Saccharomyces cerevisiae. The innovative approach is based on the combination of microcalorimetric, spectroscopic, electrochemical, and microscopic methods, which allows analysis of the toxic effect of CdTe QDs on S. cerevisiae and its mechanism. According to the values of the half inhibitory concentration (IC50), CdTe QDs exhibit marked cytotoxicity in yeast cells at concentrations as low as 80.81 nmol L?1 for green-emitting CdTe QDs and 17.07 nmol L?1 for orange-emitting CdTe QDs. QD-induced cell death is characterized by cell wall breakage and cytoplasm blebbing. These findings suggest that QDs with sizes ranging from 4.1 to 5.8 nm can be internalized into yeast cells, which then leads to QD-induced cytotoxicity. These studies provide valuable information for the design and development of aqueous QDs for biological applications.
Non-technical Summary: This study examines the toxic effect and subcellular location of cadmium telluride (CdTe) QDs with different sizes against yeast Saccharomyces cerevisiae. The innovative approach is based on the combination of microcalorimetric, spectroscopic, electrochemical, and microscopic methods, which allows analysis of the toxic effect of CdTe QDs on S. cerevisiae and its mechanism.
Content Emphasis Peer Reviewed Journal Article
Exposure Or Hazard Target Other/Unspecified
Exposure Pathway Other/Unspecified
Method Of Study Other
Paper Type Environmental Fate and Transport
Particle Type Semiconductor
Production Method Engineered
Risk Exposure Group Ecosystem
Target Audience Technical Research
Citation: Small, 8(17): 2680-2689 (September 2012)
Publication: Small
Author: Han X, Lai L, Tian F, Jiang FL, Xiao Q, Li Y, Yu Q, Li D, Wang J, Zhang Q, Zhu B, Li R, Liu Y
Volume: 8
Number: 17
Pages: 2680-2689
     


Last updated on October 19, 2012
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This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.

 		 
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