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Title: Surface modification of PAMAM dendrimer improves its biocompatibility
Date: 8/2012
  Link to Journal Abstract
Abstract: Modification of dendrimer surface groups is one of the methods available to obtain compounds characterized by reduced toxicity. This article reports results of preliminary biocompatibility studies of a modified polyamidoamine dendrimer of the fourth generation. Reaction with dimethyl itaconate resulted in transformation of surface amine groups into pyrrolidone derivatives. Interaction of the modified dendrimer with human serum albumin (HSA) was analyzed. The influence of the dendrimer on mouse neuroblastoma cell line viability and its hemolytic properties were also investigated. The binding constant between analyzed dendrimer and HSA was found to be equal to 1.2 × 105 ± 0.2 × 105 M–1. Small changes in HSA secondary structure were observed. The analyzed dendrimer revealed minor toxic activity, as diminishment in cell viability was observed only for dendrimer concentrations higher than 2 mg/mL. Moreover, under the applied experimental conditions, no hemolytic activity was observed. Those observations point to the potential of the analyzed compound for further studies toward its applicability in nanomedicine.
Non-technical Summary: This article reports results of preliminary biocompatibility studies of a modified polyamidoamine dendrimer of the fourth generation. Interaction of the modified dendrimer with human serum albumin (HSA) was analyzed. The influence of the dendrimer on mouse neuroblastoma cell line viability and its hemolytic properties were also investigated.
Content Emphasis Peer Reviewed Journal Article
Exposure Or Hazard Target Mammalian
Exposure Pathway Other/Unspecified
Method Of Study In Vitro
Paper Type Hazard
Particle Type Organic/Polymers
Production Method Engineered
Risk Exposure Group General Population
Target Audience Technical Research
Citation: Nanomedicine: Nanotechnology, Biology and Medicine, 8(6): 815-817 (August 2012)
Publication: Nanomedicine: Nanotechnology, Biology and Medicine
Author: Ciolkowski M, Petersen JF, Ficker M, Janaszewska A, Christensen JB, Klajnert B, Bryszewska M
Volume: 8
Number: 6
Pages: 815-817
     


Last updated on August 20, 2012
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This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.

 		 
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