ICON Web & News
Search Using OECD Database
Return to Previous Page
Addition or Correction
Surface modification of PAMAM dendrimer improves its biocompatibility
Link to Journal Abstract
Modification of dendrimer surface groups is one of the methods available to obtain compounds characterized by reduced toxicity. This article reports results of preliminary biocompatibility studies of a modified polyamidoamine dendrimer of the fourth generation. Reaction with dimethyl itaconate resulted in transformation of surface amine groups into pyrrolidone derivatives. Interaction of the modified dendrimer with human serum albumin (HSA) was analyzed. The influence of the dendrimer on mouse neuroblastoma cell line viability and its hemolytic properties were also investigated. The binding constant between analyzed dendrimer and HSA was found to be equal to 1.2 × 105 ± 0.2 × 105 M–1. Small changes in HSA secondary structure were observed. The analyzed dendrimer revealed minor toxic activity, as diminishment in cell viability was observed only for dendrimer concentrations higher than 2 mg/mL. Moreover, under the applied experimental conditions, no hemolytic activity was observed. Those observations point to the potential of the analyzed compound for further studies toward its applicability in nanomedicine.
This article reports results of preliminary biocompatibility studies of a modified polyamidoamine dendrimer of the fourth generation. Interaction of the modified dendrimer with human serum albumin (HSA) was analyzed. The influence of the dendrimer on mouse neuroblastoma cell line viability and its hemolytic properties were also investigated.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Nanomedicine: Nanotechnology, Biology and Medicine, 8(6): 815-817 (August 2012)
Nanomedicine: Nanotechnology, Biology and Medicine
Ciolkowski M, Petersen JF, Ficker M, Janaszewska A, Christensen JB, Klajnert B, Bryszewska M
Last updated on August 20, 2012
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
Why Join Us?
Mission and Strategy
Good Nano Guide
Nano EHS Research Needs
Current Practices Survey