International Council on Nanotechnology, Rice University - Virtual Journal

Aquatic toxicity evaluation of TiO2 nanoparticle produced from sludge of TiCl4 flocculation of wastewater and seawater

Sun, 15 Nov 2009 06:00:00 GMT

In this study the aquatic toxicity of TiCl4 flocculation process was investigated to assess the environmental safety of the coagulant using D. magna and V. fischeri bioassays - the toxicity of TiO2 nanoparticles recovered from wastewater and seawater flocculated sludge were also evaluated.
Journal of Nanoparticle Research, 11(8); 2087-2096 (November 2009)

From workplace air measurement results toward estimates of exposure? Development of a strategy to assess exposure to manufactured nano-objects

Sun, 15 Nov 2009 06:00:00 GMT

This paper describes a harmonized approach for measurement strategy, data analysis and reporting for manufactured nanomaterials that has been developed within the EU-sponsored NANOSH project.
Journal of Nanoparticle Research, 11(8); 1867-1881 (November 2009)

Neurotoxicity of manganese oxide nanomaterials

Sun, 15 Nov 2009 06:00:00 GMT

In this study, the toxicity of manganese oxide nanomaterials in a neuronal precursor cell model was examined, using the MTS assay to evaluate mitochondrial function in living cells and the LDH assay to quantify the release of the enzyme lactate dehydrogenase as a result of damage to the cell membrane.
Journal of Nanoparticle Research, 11(8); 1957-1969 (November 2009)

Thermal ignition and self-heating of carbon nanotubes: From thermokinetic study to process safety

Thu, 15 Oct 2009 06:00:00 GMT

In this study, a comprehensive investigation on the kinetics of combustion of multiwall carbon nanotubes (MWCNTs) produced by vapour chemical deposition was undertaken and a model has been developed - recommendations for a safe handling and storage of carbon nanotubes are also presented.
Chemical Engineering Science, 64(20): 4210-4221 (October 2009)

Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models

Fri, 31 Jul 2009 06:00:00 GMT

This study investigates the potential cytotoxicity of solid lipid nanoparticles (SLN) for human lung as a suitable drug delivery system (DDS) using a human alveolar epithelial cell line (A549) and murine precision-cut lung slices (PCLS) to estimate the tolerable doses of these particles for lung cells.
Inhalation Toxicology, 21(S1): 104-109 (July 2009)

European and international standardisation progress in the field of engineered nanoparticles

Fri, 31 Jul 2009 06:00:00 GMT

This paper summarizes various efforts at European and international standardisation in the field of enginneered nanoparticles and raises particular issues for toxicity at the nanoscale.
Inhalation Toxicology, 21(S1): 2-7 (July 2009)

Facing the key workplace challenge: Assessing and preventing exposure to nanoparticles at source

Fri, 31 Jul 2009 06:00:00 GMT

In this study, the key physical processes related to formation and growth of nanoparticles are characterized with the main focus on various occupational environments.
Inhalation Toxicology, 21(S1): 17-24 (July 2009)

A role for nanoparticle surface reactivity in facilitating pulmonary toxicity and development of a base set of hazard assays as a component of nanoparticle risk management

Fri, 31 Jul 2009 06:00:00 GMT

In this paper, conclusions from three pulmonary bioassay hazard/safety studies that include surface reactivity or surface treatments/coatings of particles, and aggregation potential of aerosolized particles are summarized and a concept for developing a risk assessment system for the development of new nanomaterials is presented.
Inhalation Toxicology, 21(S1): 61-67 (July 2009)

Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure

Tue, 01 Dec 2009 06:00:00 GMT

This study investigates the penetration and potential toxicity of titanium dioxide (TiO2) nanoparticles following its dermal exposure in vitro and in vivo.
Toxicology Letters 191(1): 1-8 (1 December 2009)

Toxicology of Nanomaterials: Permanent interactive learning

Wed, 28 Oct 2009 06:00:00 GMT

This editorial contains a summary of the most important outcomes of two special workshops on the toxicology of multi-wall carbon nanotubes in Nagano (Japan) and discuss some recent reports from the nanotech literature, and more specifically a Chinese study that claims severe consequences of nanoparticle exposure.
Particle and Fibre Toxicology, 2009, 6: 28 (3pp)

Optimisation of Dex-GMA nanoparticles prepared in modified micro-emulsion system: Physical and biologic characterization

Fri, 25 Sep 2009 06:00:00 GMT

In this study, glycidyl methacrylate derivatized dextran (Dex-GMA) nanoparticles encapsulating basic fibroblast growth factor (bFGF) have been prepared inside the aqueous cores of sodium bis(2-ethylhexyl) sulfosuccinate (AOT)/n-hexane reverse micelles and the impact of the nanoparticles on mouse bone marrow mesenchymal stem cells (BMSCs) was assessed with cell cytotoxicity/viability and adhesion assay.
Journal of Biotechnology, 143(4): 268-273 (September 20

Polyethyleneimine Coating Enhances the Cellular Uptake of Mesoporous Silica Nanoparticles and Allows Safe Delivery of siRNA and DNA Constructs

Tue, 27 Oct 2009 06:00:00 GMT

In this study polyethyleneimine (PEI) polymers are noncovalently attached to the surface of mesoporous silica nanoparticles - the study included an assessment of the cationic MSNP cytotoxicity for several different polymer molecular weights.
ACS Nano, 2009, 3(10), 3273-3286 October 2009

Synthesis, characterization and in vitro cytotoxicity of self-regulating magnetic implant material for hyperthermia application

Thu, 15 Oct 2009 06:00:00 GMT

This study includes an in vitro cytotoxicity assessment of the synthesized Gd-substituted zinc ferrite nanoparticles using MTT assay.
Materials Science and Engineering: C, 29(8): 2525-2529 (October 2009)

Immunological and cytotoxicological characterization of tuberculin purified protein derivative (PPD) conjugated to single-walled carbon nanotubes

Tue, 22 Sep 2009 06:00:00 GMT

This study included the analysis for cytotoxicity of carboxylated single-walled carbon nanotubes (SWCNT) and an SWCNT-tuberculin purified protein derivative conjugate with MTT assay and by reactive oxygen species (ROS) and nitric oxide (NO) generation.
Immunology Letters, 126(1-2): 48-53 (September 2009)

Evaluation of Silver Nanoparticle Toxicity in vivo Skin and in vitro Keratinocytes

Fri, 23 Oct 2009 06:00:00 GMT

This study was designed to assess the potential cytotoxicity of Ag-nps in human epidermal keratinocytes (HEK), and their inflammatory and penetrating potential into porcine skin in vivo.
Environmental Health Perspectives, 2009 EHP-in-Press DOI: 10.1289/ehp.0901398

Barrier Capacity of Human Placenta for Nanosized Materials

Sun, 15 Nov 2009 06:00:00 GMT

In this study, the ex-vivo human placental perfusion model was used to investigate ifnanoparticles can cross the placental barrier and if this process is size dependent.
Environmental Health Perspectives, 2009 EHP-in-Press DOI: 10.1289/ehp.0901200

Surface modified poly(amido)amine dendrimers as diverse nanomolecules for biomedical applications

Mon, 31 Aug 2009 06:00:00 GMT

This review presents brief discussion on current surface modification approaches to: i) increase targeting efficiency; ii) increase the cellular permeability for enhanced absorption; iii) increase gene transfection efficiency; and iv) decrease the toxicity of poly(amido)amine dendrimers.
Expert Opinion on Drug Delivery, 6(8): 835-850 (August 2009)

The role of nanoparticle concentration-dependent induction of cellular stress in the internalization of non-toxic cationic magnetoliposomes

Sun, 20 Dec 2009 06:00:00 GMT

In this study, a cationic peptide–lipid conjugate (dipalmitoylphosphatidylethanolamine-succinyl-tetralysine [DPPE-succ-(Lys)4]) which is entirely composed of biodegradable moieties and specifically designed to exert minimal cytotoxic effects was synthesized and tested in uptake studies with both murine 3T3 fibroblasts and C17.2 neural progenitor cells.
Biomaterials 30(36): 6803-6813 (December 2009)

Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells

Sun, 15 Nov 2009 06:00:00 GMT

This study examined the effects of nano-sized titanium dioxide (TiO2) on poorly tumorigenic and nonmetastatic QR-32 fibrosarcoma cells to better understand the contribution of nanomaterials to carcinogenesis.
American Journal of Pathology, 2009 175(5): 2171-2183

Amperometric assessment of functional changes in nanoparticle-exposed immune cells: varying Au nanoparticle exposure time and concentration

Sun, 15 Nov 2009 06:00:00 GMT

In this study, a mast cell/fibroblast co-culture system is used as a model to assess the toxicity of gold nanoparticles over the course of 72 hours of exposure.
Analyst 2009, 134(11): 2293-2300

"Nobody Told Me I was a Nano-Consumer:" How Nanotechnologies Might Challenge the Notion of Consumer Rights

Thu, 05 Nov 2009 06:00:00 GMT

This study reports on a Norwegian study with data derived from focus groups, a content analysis of advertisements, packaging and labels for cosmetics as well as on a Norwegian consumer survey.
Journal of Consumer Policy, Online First, DOI: 10.1007/s10603-009-9114-9

Titanium Dioxide Nanoparticles Induce DNA Damage and Genetic Instability In vivo in Mice

Sun, 15 Nov 2009 06:00:00 GMT

This study investigates TiO2 nanoparticles–induced genotoxicity, oxidative DNA damage, and inflammation in a mice model by treating wild-type mice with TiO2 nanoparticles in drinking water and determining the extent of DNA damage using various assays.
Cancer Research 69(22): 8784-8789 (November 2009)

Cryo-electron tomography of nanoparticle transmigration into liposome

Tue, 01 Dec 2009 06:00:00 GMT

This study reports on the transport of hydrophilic silica nanoparticles into large unilamellar neutral DOPC liposomes via an internalization process.
Journal of Structural Biology, 168(3): 419-425 (December 2009)

Silver nanoparticles inhibit VEGF induced cell proliferation and migration in bovine retinal endothelial cells

Mon, 05 Oct 2009 06:00:00 GMT

This study investigated the anti-angiogenic potential of silver nanoparticles, produced by Bacillus licheniformis. Bovine retinal endothelial cells (BRECs) were treated with the different concentrations of silver nanoparticles for 24 h in the presence and absence of vascular endothelial growth factor (VEGF) to determine how silver nanoparticles would be able to block the proliferation and migration of BRECs.
Colloids and Surfaces B: Biointerfaces, 73(1): 51-57 (1 October 2009)

In vitro translocation of quantum dots and influence of oxidative stress

Thu, 05 Nov 2009 06:00:00 GMT

In this study, the translocation of nano-sized quantum dots (QDs; 25 pmol/ml) through a tight monolayer of primary isolated rat alveolar epithelial cells was investigated, in vitro. The influence of surface charge on translocation was examined using nonfunctionalized QDs, amine-QDs, and carboxyl-QDs.
Am J Physiol Lung Cell Mol Physiol 297(5): L903-L911 (November, 2009)

Silver Nanoparticle Impact on Bacterial Growth: Effect of pH, Concentration, and Organic Matter

Thu, 01 Oct 2009 06:00:00 GMT

This study investigated the impact on Pseudomonas fluorescens over a 24 h exposure of well characterized silver nanoparticles at pH values of 6−9, in the presence and absence of Suwannee River humic acids (SRHA).
Environ. Sci. Technol., 2009, 43(19): 7285-7290

Fate of Silica Nanoparticles in Simulated Primary Wastewater Treatment

Sun, 15 Nov 2009 06:00:00 GMT

In this study, the fate of functionalized and unfunctionalized silica nanoparticles (SiO2NPs) during simulated primary wastewater treatment was examined by measuring, in real time, the colloidal behavior of SiO2NPs in wastewater (sewage).
Environ. Sci. Technol., 2009, 43(22): 8622-8628

Interactions of Silver Nanoparticles with Pseudomonas putida Biofilms

Fri, 30 Oct 2009 06:00:00 GMT

In this study, the interactions between silver nanoparticles and laboratory-grown Pseudomonas putida biofilms were investigated under a range of environmentally relevant conditions (pH 6 and 7.5; presence and absence of Suwannee River fulvic acid (SRFA)) over 4 days.
Environ. Sci. Technol, 2009, Article ASAP, DOI: 10.1021/10.1021/es901706j

Transport of Iron-Based Nanoparticles: Role of Magnetic Properties

Wed, 04 Nov 2009 06:00:00 GMT

In this study, the transport of magnetic nanoparticles in aquatic environments was studied in packed bed columns using maghemite (ã-Fe2O3) and ã-Fe2O3 based (FexNi1−x)yOz nanoparticles as a function of pH and particle iron content that induced a different magnetic property.
Environ. Sci. Technol, 2009, Article ASAP, DOI: 10.1021/es9015525

Modeled Environmental Concentrations of Engineered Nanomaterials (TiO2, ZnO, Ag, CNT, Fullerenes) for Different Regions

Mon, 09 Nov 2009 06:00:00 GMT

In this study, the predicted environmental concentrations (PEC) based on a probabilistic material flow analysis from a life-cycle perspective of negineered nanomaterial-containing products were calculated. Nano-TiO2, nano-ZnO, nano-Ag, carbon nanotubes (CNT), and fullerenes were modeled for the U.S., Europe and Switzerland.
Environ. Sci. Technol, 2009, Article ASAP, DOI: 10.1021/es9015553

Single-Walled Carbon Nanotubes Exhibit Limited Transport in Soil Columns

Wed, 11 Nov 2009 06:00:00 GMT

In this study, the transport behavior of carboxyl-functionalized single-walled carbon nanotubes (SWNTs) in columns packed with a natural soil was investigated.
Environ. Sci. Technol, 2009, Article ASAP, DOI: 10.1021/es901927y

Nanostructured TiO2: Transport Behavior and Effects on Aquatic Microbial Communities under Environmental Conditions

Sun, 01 Nov 2009 06:00:00 GMT

In this research, experiments with different TiO2 nanoparticles in stream microcosms have been conducted to have a better understanding of the behavior of engineered nanoparticles in aquatic ecosystems and their impact on complex communities.
Environ. Sci. Technol., 2009, 43(21): 8098-8104

Carbon Dots as Nontoxic and High-Performance Fluorescence Imaging Agents

Thu, 22 Oct 2009 06:00:00 GMT

In this study fluorescent carbon dots (small carbon nanoparticles with the surface passivated by oligomeric PEG molecules) were evaluated for their cytotoxicity and in vivo toxicity.
J. Phys. Chem. C, 2009, 113(42): 18110-18114

Systemic scenarios of nanotechnology: Sustainable governance of emerging technologies

Tue, 30 Jun 2009 06:00:00 GMT

This paper presemts a scenario study on possible future developments of nanotechnology in Switzerland (reference year 2020). The study employed a formalized and functional scenario methodology, featuring system analysis, consistency analysis and transdisciplinary collaboration which is recommended as a valuable tool for the sustainable governance of emerging technologies.
Futures, 41(5): 284-300 (June 2009)

Nanoscale and Fine Zinc Oxide Particles: Can in Vitro Assays Accurately Forecast Lung Hazards following Inhalation Exposures?

Thu, 15 Oct 2009 06:00:00 GMT

This study compares lung toxicity impacts of nanoscale (NZnO) vs fine zinc oxide (FZnO) particulates, assess predictability of in vitro cell culture systems, and compare effects of instillation vs inhalation exposures in rats.
Environ. Sci. Technol., 2009, 43(20): 7939-7945

Assessing cytotoxicity of (iron oxide-based) nanoparticles: an overview of different methods exemplified with cationic magnetoliposomes

Fri, 30 Oct 2009 06:00:00 GMT

In this review, a small overview of commonly used assays to assess the biocompatibility of nanoparticles is presented in order to assess several aspects, such as cell viability, induction of reactive oxygen species, nanoparticle uptake, cellular morphology, cellular proliferation, actin cytoskeleton architecture and differentiation of stem cells. The main focus is on comparing the advantages and disadvantages of the different assays,
Contrast Media & Molecular Imaging, 4(5): 207-219 (October 2009)

Methylated N-aryl chitosan derivative/DNA complex nanoparticles for gene delivery: Synthesis and structure-activity relationships

Tue, 17 Nov 2009 06:00:00 GMT

In this study, three kinds of methylated chitosan containing different aromatic moieties as particle complexes were synthesized and characterized. efficiencies of these complexes were investigated and the cytotoxicity of these complexes were also studied by MTT assay.
Carbohydrate Polymers, 78(4): 743-752 (November 2009)

Nanoparticles can cause DNA damage across a cellular barrier

Thu, 05 Nov 2009 06:00:00 GMT

In this study, the ability of cobalt-chromium nanoparticles (29.5 6.3 nm in diameter) to damage human fibroblast cells across an intact cellular barrier without having to cross the barrier is examined in order to understand the importance of indirect effects when evaluating the safety of nanoparticles.
Nature Nanotechnology, Advanced Online Publication, DOI: 10.1038/nnano.2009.313

In vitro interactions between splenocytes and dansylamide dye-embedded nanoparticles detected by flow cytometry

Wed, 30 Sep 2009 06:00:00 GMT

A novel method for visualizing engineered nanoparticles within cells using standard flow-cytometric techniques is reported in this paper.
Nanomedicine: Nanotechnology, Biology and Medicine, 5(3): 298-304 (September 2009)

In Vitro Antiviral Effect of Nanosilver on Influenza Virus

Tue, 30 Jun 2009 06:00:00 GMT

The aim of this study was to determine antiviral effects of Nanosilver against influenza virus.
DARU - Journal of Faculty of Pharmacy, 17(2): 88-93 (June 2009)

Biocompatibility analysis of magnetic hydrogel nanocomposites based on poly(N-isopropylacrylamide) and iron oxide

Tue, 01 Dec 2009 06:00:00 GMT

In this study, magnetic hydrogel nanocomposites based on poly(N-isopropylacrylamide) and iron oxide nanoparticles were fabricated via UV-polymerization with tetra(ethylene glycol) dimethacrylate acting as the crosslinking agent and in vitro biocompatibility analysis via NIH 3T3 murine fibroblast cytotoxicity was investigated.
Journal of Biomedical Materials Research Part A, 91A(3): 903-909 (December 2009)

The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2

Mon, 02 Nov 2009 06:00:00 GMT

In this study, nano-anatase TiO2 (5 nm) was injected into the abdominal cavity of ICR mice for consecutive 14 days, and the inflammatory responses of liver of mice was investigated.
Nanoscale Research Letters, 4(11): 1275-1285 (November 2009)

Synthesis and Characterization of Biocompatible and Size-Tunable Multifunctional Porous Silica Nanoparticles

Tue, 08 Sep 2009 06:00:00 GMT

In this work, size-controlled multifunctional mesoporous silica nanoparticles having large surface areas, embedded luminescence, high magnetization, and excellent aqueous dispersity are prepared and characterized and in vitro assays were performed to evaluate any unintended cytotoxicity.
Chemistry of Materials, 21(7): 3979-3986 (September 2009)

Inhaled fluorescent magnetic nanoparticles induced extramedullary hematopoiesis in the spleen of mice

Wed, 30 Sep 2009 06:00:00 GMT

In this study, inhalation toxicity of manufactured nanomaterials using fluorescent magnetic nanoparticles (FMNPs) in biological samples from a previous mouse FMNP exposure experiment was assessed to address the issue of potential nanoparticle toxicity.
Journal of Occupational Health, 51(5): 423-431 (September 2009)

Supercooled smectic nanoparticles: Influence of the matrix composition and in vitro cytotoxicity

Thu, 08 Oct 2009 06:00:00 GMT

Cholesteryl nonanoate (CN), myristate (CM), palmitate (CP) and oleate (CO) alone or in combination were evaluated as matrix lipids for the preparation of supercooled smectic nanoparticles with a high stability against recrystallization during storage. The cytotoxicity of selected formulations was compared with that of a clinically used colloidal fat emulsion (Lipofundin MCT) in the murine fibroblast cell line L929 using the sulforhodamine B assay.
European Journal of Pharmaceutical Sciences, 38(3): 238-248 (October 2009)

Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure

Tue, 01 Dec 2009 06:00:00 GMT

In this study, the impacts of both short-term and long-term exposure to nano-TiO2 on enhanced cell proliferation, survival, ERK signaling activation and ROS production in cultured fibroblast cells were investigated.
Toxicology and Applied Pharmacology 241(2), 182-194 (December 2009)

Risk analysis and protection measures in a carbon nanofiber manufacturing enterprise: An exploratory investigation

Sun, 01 Nov 2009 06:00:00 GMT

In this study, a four-step methodology was developed to protect worker health in the nano-manufacturing enterprise through the generation of improvement actions followed by interventions. The methodology was implemented in a carbon nanofiber manufacturing enterprise in the Midwest of the US. The data collected were based on detailed observations and interviews with worker and management personnel.
Science of the Total Environment, 407(22): 5825-5838 (November 2009)

Nanoparticle dermal absorption and toxicity: a review of the literature

Fri, 23 Oct 2009 06:00:00 GMT

This article reviews the literature on the percutaneous absorption of nanoparticles and their effect on skin.
International Archives of Occupational and Environmental Health, 82(9): 1043-1055 (October 2009)

Proposed Minimum Characterization Parameters for Studies on Food and Food-Related Nanomaterials

Thu, 15 Oct 2009 06:00:00 GMT

The continued development and application of nanotechnology in food science give reason to pause and take stock of the current status of nanomaterial definition, characterization, and safety testing in this area. This letter proposesthat a set of minimum parameters be determined and reported for nanomaterials that are used in experiments assessing various biological activities,
Journal of Food Science, 74(8): vi-vii (October 2009)

Exchange of TiO2 Nanoparticles between Streams and Streambeds

Thu, 15 Oct 2009 06:00:00 GMT

In this study, laboratory flume, column, and batch experiments were conducted to investigate the processes dominating the transport of TiO2 nanoparticles between streams and streambeds and to characterize the properties of these nanoparticles under different physicochemical conditions.
Environ. Sci. Technol., 2009, 43(20): 7699-7705

PLGA Nanoparticles Stabilized with Cationic Surfactant: Safety Studies and Application in Oral Delivery of Paclitaxel to Treat Chemical-Induced Breast Cancer in Rat

Wed, 04 Nov 2009 06:00:00 GMT

In this study, poly(lactide-co-glycolide) (PLGA) nanoparticles were formulated using a quaternary ammonium salt didodecyl dimethylammonium bromide (DMAB)- these particles were evaluated by MTT and LDH cytotoxicity assays.
Pharmaceutical Research, 26(11): 2495-2503 (November 2009)

Synthesis, characterization, cytotoxicity and antibacterial studies of chitosan, O-carboxymethyl and N,O-carboxymethyl chitosan nanoparticles

Tue, 17 Nov 2009 06:00:00 GMT

In this study, the nanoparticles of CS and its water-soluble derivatives such as O-carboxymethyl chitosan (O-CMC) and N,O-carboxymethyl chitosan (N,O-CMC) was synthesized and characterized. In addition, cytotoxicity and antibacterial activity of the prepared nanoparticles was also evaluated.
Carbohydrate Polymers, 78(4): 672-677 (November 2009)

Community Engagement to Facilitate, Legitimize and Accelerate the Advancement of Nanotechnologies in Australia

Sat, 24 Oct 2009 06:00:00 GMT

Through an analysis of a number of Australia’s nano-engagement activities, this paper evaluates public engagement related to the development of nanotechnology related policies and regulation in Australia.
NanoEthics, 2009, Online First, DOI: 10.1007/s11569-009-0070-2

Influence of Multiwalled Carbon Nanotubes Dispersed in Natural Organic Matter on Speciation and Bioavailability of Copper

Fri, 23 Oct 2009 06:00:00 GMT

In this study, the speciation and bioavailability of copper (Cu) in carbon MWNTs-associated NOM was studied using Daphnia magna.
Environ. Sci. Technol, 2009, Article ASAP, DOI: 10.1021/es900647f

Studies on toxicity of multi-walled carbon nanotubes on suspension rice cells

Wed, 02 Dec 2009 06:00:00 GMT

In this study, suspension rice cells (Oryza sativa L.) were cultured with multi-walled carbon nanotubes (MWCNTs)and oxygen species (ROS) increased and cell viability were measured in order to investigate possible toxic effects of (MWCNTs) on plant cells.
Carbon, 47(15): 3479-3487 (December 2009)

A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles

Fri, 30 Oct 2009 06:00:00 GMT

In this study, the cytotoxicity of superparamagnetic iron oxide nanoparticle (SPIONs) and the effect of the particles on the cell medium components was investigated by exposing SPIONs to the mouse fibroblast cell line L929.
Colloids and Surfaces B: Biointerfaces, 2009 Article in Press, DOI: 10.1016/j.colsurfb.2009.08.044

Biocompatible Near-Infrared Quantum Dots as Ultrasensitive Probes for Long-Term in vivo Imaging Applications

Fri, 04 Sep 2009 06:00:00 GMT

In this study monodisperse, biocompatible, lysine crosslinked mercaptoundecanoic acid (MUA) CdSe0.25Te0.75/CdS near-infrared (NIR) quantum dots are produced for use as probes to study their long term in vivo distribution, clearance, and toxicity.
Small 2009, 5(17), 1997-2004 (September 2009)

Comparative cytotoxicity of five current dentin bonding agents: Role of cell cycle deregulation

Sun, 01 Nov 2009 06:00:00 GMT

This study compares the cytotoxicity of three nano-dentin bonding agents (nano-DBAs) and two non-nano-DBAs using Chinese hamster ovary (CHO-K1) cells.
Acta Biomaterialia, 5(9): 3404-3410 (November 2009)

JEM Spotlight: Environmental monitoring of airborne nanoparticles

Sat, 31 Oct 2009 06:00:00 GMT

This article reviews the existing instrumental methods to monitor airborne nanoparticles in different types of indoor and outdoor environments in order to detect their presence and to characterise their properties.
Journal of Environmental Monitoring, 11(10): 1758-1773 (October 2009)

Sensors as tools for quantitation, nanotoxicity and nanomonitoring assessment of engineered nanomaterials

Sat, 31 Oct 2009 06:00:00 GMT

This article discusses emerging fields of nanotoxicology and nanomonitoring including the challenges of characterizing engineered nanomaterials and the potentials of combining existing analytical techniques with conventional cytotoxicity methods.
Journal of Environmental Monitoring, 11(10): 1782-1800 (October 2009)

On the interaction of nano-sized organic carbon particles with model lipid membranes

Sun, 01 Nov 2009 06:00:00 GMT

In this study, the interaction of nano-sized organic carbon particles (NOCs), produced in ordinary combustion processes, with cell-sized unilamellar vesicles was investigated. investigation was performed by spectroscopically analyzing the chemical modifications of membrane lipid tails in optically trapped vesicles after exposure to NOCs.
Carbon, 47(13): 2950-2957 (November 2009)

Fullerene Exposures with Oysters: Embryonic, Adult, and Cellular Responses

Tue, 15 Sep 2009 06:00:00 GMT

Fullerene (C60) exposure studies with oysters, Crassostrea virginica, were conducted with a variety of biological levels, e.g., developmental studies with embryos, whole organism exposures with adults, and isolated hepatopancreas cells.
Environ. Sci. Technol., 2009, 43(18): 7136-7141

Studies on toxicity of multi-walled carbon nanotubes on Arabidopsis T87 suspension cells

Fri, 30 Oct 2009 06:00:00 GMT

The possible toxicities of agglomerates of multi-walled carbon nanotubes (MWCNTs) toward plant cells were evaluated in this study using Arabidopsis T87 suspension cells as the model cells.
Journal of Hazardous Materials, 170(2-3): 578-583 (October 2009)

The Behavior of Silver Nanotextiles during Washing

Sun, 01 Nov 2009 06:00:00 GMT

This study was undertaken to determine the amount and the form of Ag released during washing from nine fabrics with different ways of silver incorporation into or onto the fibers. The effect of pH, surfactants, and oxidizing agents was evaluated.
Environ. Sci. Technol., 2009, 43(21): 8113-8118

Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability

Sun, 01 Nov 2009 06:00:00 GMT

This study was undertaken to explore quantum dot-induced metabolic changes, which could occur without any apparent cellular damage.
FEBS Journal, 276(21): 6204-6217 (November 2009)

Positively charged and pH self-buffering quantum dots for efficient cellular uptake by charge mediation and monitoring cell membrane permeability

Wed, 21 Oct 2009 06:00:00 GMT

Positively charged and pH self-buffering quantum dots (Tren-QDs) were achieved by surface functionalization with tris(2-aminoethyl)amine (Tren) derivatives and studied under physiological conditions to determine their cellular uptake efficiency.
Nanotechnology 2009 20(42): 425102 (8pp)

Immunostimulatory properties and enhanced TNF-alpha mediated cellular immunity for tumor therapy by C60(OH)20 nanoparticles

Wed, 14 Oct 2009 06:00:00 GMT

In this paper, water-soluble C60(OH)20 nanoparticles are tested for anti-tumor activity in vivo and specific immunomodulatory effects to the immune cells, such as T cells and macrophages, both in vivo and in vitro.
Nanotechnology 2009 20(41): 415102 (10pp)

The hepatotoxicity of multi-walled carbon nanotubes in mice

Wed, 04 Nov 2009 06:00:00 GMT

In this study, the hepatotoxicity of two types of multi-walled carbon nanotubes (MWCNTs), acid-oxidized MWCNTs (O-MWCNTs) and Tween-80-dispersed MWCNTs (T-MWCNTs), were investigated with Kunming mice exposed to 10 and 60 mg kg−1 by intravenous injection for 15 and 60 d.
Nanotechnology 2009 20(44): 445101 (9pp)

Formulation of novel lipid-coated magnetic nanoparticles as the probe for in vivo imaging

Mon, 21 Sep 2009 06:00:00 GMT

In this study, new cationic lipid nanoparticles containing superparamagnetic iron oxide nanoparticles (SPIOs) feasible for in vivo imaging were formulated and HeLa, PC-3 and Neuro-2a cells were tested for loading efficiency and cytotoxicity of Lipid-SPIOs using fluorescent microscopy, Prussian blue staining and flow cytometry.
Journal of Biomedical Science, 2009 16:86 (10 pp)

In vitro evaluation of the genotoxicity of a family of novel MeO-PEG-poly(D,L-lactic-co-glycolic acid)-PEG-OMe triblock copolymer and PLGA nanoparticles

Wed, 11 Nov 2009 06:00:00 GMT

In this study, the cytotoxicity and genotoxicity of nine kinds of selected blank PELGE and PLGA (poly(D,L-lactic and glycolic acid)) nanoparticles were evaluated using methyl thiazolyl tetrazolium (MTT), micronucleus (MN) and sister chromatid exchange (SCE) assays with or without the addition of a metabolic activation system (S9 mix), using Chinese hamster ovary (CHO) cells.
Nanotechnology 2009 20(45): 455102 (8pp)

The biocompatibility of fluorescent nanodiamonds and their mechanism of cellular uptake

Wed, 21 Oct 2009 06:00:00 GMT

This study evaluates the biocompatibility and the mechanism of the cellular uptake of fluorescent nanodiamonds (FNDs) in cancer cells (HeLa) and pre-adipocytes (3T3-L1).
Nanotechnology 2009 20(42): 425103 (9pp)

Stratum Corneum Is an Effective Barrier to TiO2 and ZnO Nanoparticle Percutaneous Absorption

Mon, 05 Oct 2009 06:00:00 GMT

In this study, nuclear microscopy techniques provided spatially resolved quantitative analysis of TiO2 and ZnO nanoparticle distributions in transversal cryosections of skin obtained by biopsy with no further treatment.
Skin Pharmacology and Physiology, 22(5): 266-275 (October 2009)

Biocompatible epoxy modified bio-based polyurethane nanocomposites: Mechanical property, cytotoxicity and biodegradation

Tue, 01 Dec 2009 06:00:00 GMT

In this study, epoxy modified Mesua ferrea L. seed oil (MFLSO) based polyurethane nanocomposites with different weight % of clay loadings (1%, 2.5% and 5%) have been evaluated as biocompatible materials.
Bioresource Technology, 100(24): 6391-6397 (December 2009)

Taking Temperature - A Review of European Union Regulation in Nanomedicine

Wed, 30 Sep 2009 06:00:00 GMT

This paper introduces the emerging field of nanomedicine and then proceeds to detail the current regulatory framework and regulatory bodies in the European Union relating to medicinal products, medical devices, biologics and therapies. This is followed by a detailed analysis of two nanomedical applications in the context of regulatory challenges.
European Journal of Health Law, 2009, 16(3): 249-269

Escherichia coli Inactivation by Water-Soluble, Ozonated C60 Derivative: Kinetics and Mechanisms

Thu, 01 Oct 2009 06:00:00 GMT

In this study antibacterial and bactericidal effects of a C60 derivative prepared via excess ozonation of C60 aggregates in water were investigated using Escherichia coli as a representative microorganism.
Environ. Sci. Technol., 2009, 43(19): 7410-7415

Study of Transfection Efficiencies of Cationic Glyconanoparticles of Different Sizes in Human Cell Line

Wed, 30 Sep 2009 06:00:00 GMT

In this study the use of gold nanoparticles of different sizes as a gene delivery agent is reported. The gold nanoparticles were surface functionalized with cationic glycopolymer, and their biocompatibility under physiological conditions was investigated.
ACS Appl. Mater. Interfaces, 2009, 1(9): 1980–1987

Ocular Delivery of Compacted DNA-Nanoparticles Does Not Elicit Toxicity in the Mouse Retina

Mon, 12 Oct 2009 06:00:00 GMT

In this study the ocular safety of compacted DNA nanoparticles was investigated; polyethylene glycol-substituted lysine peptide (CK30PEG)-compacted DNA nanoparticles containing an EGFP expression plasmid were subretinally injected in adult mice.
PLoS ONE 4(10): e7410 (11 pp)

Anti-proliferative activity of silver nanoparticles

Thu, 17 Sep 2009 06:00:00 GMT

In this study, normal human lung fibroblasts (IMR-90) and human glioblastoma cells (U251) were exposed to different doses of silver nanoparticles in vitro.
BMC Cell Biology 2009, 10:65 (14 pp)

Nanocrystalline titanium dioxide and magnesium oxide in vitro dermal absorption in human skin

Tue, 30 Jun 2009 06:00:00 GMT

The dermal absorption potential of a nanocrystalline magnesium oxide (MgO) and titanium dioxide (TiO2) mixture in dermatomed human skin was assessed in vitro using Bronaugh-type flow-through diffusion cells.
Cutaneous and Ocular Toxicology, 28(2): 78-82 (June 2009)

Investigating the Immunologic Effects of CoCr Nanoparticles

Sun, 01 Nov 2009 06:00:00 GMT

This study determined changes in the integrity and function of cells of the immune system after exposure to CoCr nanoparticles in specific cell culture experiments.
Clinical Orthopaedics and Related Research, 467(11): 3010-3016 (November 2009)

Setting the limits for engineered nanoparticles in European surface waters - are current approaches appropriate?

Thu, 15 Oct 2009 06:00:00 GMT

This review provides an insight to the likely scenarios if an engineered nanoparticle should be considered a priority substance in the European Water Framework Directive.
Journal of Environmental Monitoring, 11(10): 1774-1781 (October 2009)

The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens

Sat, 10 Oct 2009 06:00:00 GMT

This article characterizes the use, safety, and regulatory state of nanosized particles in titanium dioxide and zinc oxide in sunscreens based on studies and position statements from 1980 to 2008.
Journal of the American Academy of Dermatology, 61(4): 685-692 (October 2009)

Interaction between silver nanoparticle and bovine hemoglobin at different temperatures

Thu, 15 Oct 2009 06:00:00 GMT

The binding of silver nanoparticles to bovine hemoglobin (BHb) was studied by fluorescence, UV–Visible, and circular dichroism (CD) spectroscopic techniques at different temperatures of 20, 37, and 42 deg C.
Journal of Nanoparticle Research, 11(7); 1751-1758 (October 2009)

Characterization of exposure to silver nanoparticles in a manufacturing facility

Thu, 15 Oct 2009 06:00:00 GMT

This study monitored and analyzed the exposure characteristics of silver nanoparticles during a liquid-phase process in a commercial production facility.
Journal of Nanoparticle Research, 11(7); 1705-1712 (October 2009)

National nanotechnology partnership to protect workers

Thu, 15 Oct 2009 06:00:00 GMT

In this paper, a national partnership led by NIOSH involving nanotech manufacturers and downstream users, workers, academic researchers, safety, and health practitioners is proposed to protect workers from nanomaterials, whose risks are just emerging.
Journal of Nanoparticle Research, 11(7); 1673-1683 (October 2009)

Distinguishing nanomaterial particles from background airborne particulate matter for quantitative exposure assessment

Thu, 15 Oct 2009 06:00:00 GMT

In this article, examples of exposure assessment in nanomaterial industries are reviewed with a focus on distinguishing engineered nanomaterial particles from background nanoparticles in workplace atmosphere.
Journal of Nanoparticle Research, 11(7); 1651-1659 (October 2009)

Relevance of aerosol dynamics and dustiness for personal exposure to manufactured nanoparticles

Thu, 15 Oct 2009 06:00:00 GMT

Dustiness testing can provide insight into the state of agglomeration of particles released during handling of bulk MNP powder. Test results, supported by field data, are discussed in this study.
Journal of Nanoparticle Research, 11(7); 1637-1650 (October 2009)

Optimisation of a thermophoretic personal sampler for nanoparticle exposure studies

Thu, 15 Oct 2009 06:00:00 GMT

A new Thermal Precipitator (TP) was developed as a personal sampler for nanoparticle exposure studies.
Journal of Nanoparticle Research, 11(7); 1611-1624 (October 2009)

Comparison of four mobility particle sizers with different time resolution for stationary exposure measurements

Thu, 15 Oct 2009 06:00:00 GMT

In this study, four mobility particle sizers for measuring particle number size distributions have been subject to a detailed intercomparison study using either NaCl or diesel soot particles.
Journal of Nanoparticle Research, 11(7); 1593-1609 (October 2009)

Occupational safety and health in nanotechnology and Organisation for Economic Cooperation and Development

Thu, 15 Oct 2009 06:00:00 GMT

This article describes OECD activities around occupational safety and health of nanotechnology and provides state-of-the-science overview resulting from an OECD workshop on exposure assessment and mitigation for nanotechnology workplace.
Journal of Nanoparticle Research, 11(7); 1587-1591 (October 2009)

The slings and arrows of communication on nanotechnology

Thu, 15 Oct 2009 06:00:00 GMT

This article provides greater insight into risk perception and concludes that the positive attitude to nanotechnology is based not on knowledge but on hope and fascination.
Journal of Nanoparticle Research, 11(7); 1555-1571 (October 2009)

Investigation of airborne nanopowder agglomerate stability in an orifice under various differential pressure conditions

Thu, 15 Oct 2009 06:00:00 GMT

In order to simulate shear forces and study their effect on particle agglomerate stability within the airborne state, a method was developed where agglomerate powders can be aerosolized and passed through an orifice under various differential pressure conditions.
Journal of Nanoparticle Research, 11(7); 1625-1635 (October 2009)

Inhaled carbon nanotubes reach the subpleural tissue in mice

Sun, 01 Nov 2009 06:00:00 GMT

In this study, mice were exposed to multiwalled carbon nanotubes in a single inhalation exposure for 6 hours and the impact on the subpleural wall and within subpleural macrophages were evaluated.
Nature Nanotechnology, 4(11): 747-751 (November 2009)